Royal Brompton Hospital, National Heart and Lung Institute, Imperial College, London, UK; Département Hospitalo-Universitaire FIRE, Paris, France; Laboratory for Vascular Translational Science, INSERM U-1148, Paris, France; French Alliance for Cardiovascular Clinical Trials, F-CRIN Network, France; Université de Paris, Hôpital Bichat, Assistance Publique – Hôpitaux de Paris, Paris, France