07
Jul
2020
17:00
BST
Webinar
Emerging Evidence in Left Atrial Appendage Occlusion vs. Oral Anticoagulation Therapy with NOAC
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Overview
Transcatheter left atrial appendage occlusion (LAAO) is proven non-inferior to warfarin in atrial fibrillation (AF). However, novel oral anticoagulation (NOAC) is now preferred over warfarin as thromboprophylaxis in AF. This study sought to investigate clinical outcome and prognosis in patients with AF treated with either LAAO or NOAC.
Based on the global prospective Amulet Observational Registry (n=1,088), the faculty performed a follow-up study using propensity score 1:2 matching with replacement. A group of 18,570 patients with incident AF and treatment with NOAC (time period 2013-2015) was identified through the Danish National Patient Registry and the Danish National Prescription Registry.
The primary outcome was a composite of ischemic stroke, systemic embolism, major bleeding and all-cause mortality. Secondary outcomes were the individual endpoints of ischemic stroke, major bleeding and all-cause mortality. Both cohorts included the analysis for 2 years of follow-up.
Here, the study author and panelists discuss the findings and wider implications for clinical practice in further detail.
Faculty:
Jens Erik Nielsen-Kudsk
A John Camm
Vivek Reddy
This webinar is supported by
Learning Objectives
- Review of study results. What does the latest data tell us?
- Discussion on study importance and why this information is important?
- Discussion on clinical insights & impact for future LAAO vs NOAC drug studies
- Outlook for global CATALYST trial evaluating safety and effectiveness of Amulet compared to NOAC therapy
Audience
- Interventional Cardiologists implanting LAAO devices
- Electrophysiologists implanting LAAO devices
- Stroke specialists: Neurologists, General Cardiologists managing high risk ischemic stroke patients
- Gastroenterologists managing patients who have had or at high risk for bleeding from oral anticoagulant therapy
- Nephrologists managing patients who have had or at high risk for bleeding from oral anticoagulant therapy
Faculty Biographies
A John Camm
Professor John Camm became Professor of Clinical Cardiology at St. George’s University of London 1986. He continues to hold this positions alongside positions as Professor of Clinical Cardiology at St George’s Hospital London and Professor of Cardiology at Imperial College London.
An internationally renowned expert in atrial fibrillation (AF), Prof Camm leads the European Network for translational research in atrial fibrillation, which works towards a better understanding of AF. Other research interests include ventricular tachycardia, cardiomyopathy, pacemakers and sudden cardiac death.
Professor Camm is a Senior Consulting Editor for the European Heart Journal and Editor of the European Society of Cardiology Textbook of Cardiovascular Medicine. He has received numerous awards for his contributions to cardiology, including the British Cardiovascular Society Mackenzie Medal and the European Society of Cardiology Gold Medal.
Vivek Reddy
Dr Vivek Y Reddy, MD is Director of Cardiac Arrhythmia Services for The Mount Sinai Hospital and the Mount Sinai Health System, and The Leona M. and Harry B. Helmsley Charitable Trust Professor of Medicine in Cardiac Electrophysiology at Icahn School of Medicine at Mount Sinai, New York, US.